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Giant Papillary Conjunctivitis (GPC)


Giant Papillary Conjunctivitis (GPC) is a type of chronic allergic conjunctivitis that typically occurs in people who wear contact lenses, especially soft lenses or those worn for extended periods. It is characterized by the formation of large, red, and inflamed bumps (papillae) on the inner surface of the upper eyelid, which can cause discomfort, itching, and excessive mucus production. GPC is triggered by a combination of mechanical irritation from the contact lenses and an allergic reaction to protein deposits on the lenses. The condition can make wearing contact lenses uncomfortable and, in severe cases, intolerable.

  • Causes: GPC is caused by the constant friction of contact lenses against the inner eyelid, combined with an allergic reaction to proteins, bacteria, or other debris that accumulates on the lenses. Poor lens hygiene, overuse of lenses, or wearing lenses overnight can increase the risk of developing GPC.
  • Symptoms: Symptoms of GPC include itching, discomfort, a sensation of something in the eye, redness, mucus discharge, blurry vision, and difficulty wearing contact lenses. The condition can also lead to swelling and sensitivity to light.
  • Treatment: The primary treatment for GPC involves discontinuing contact lens use to allow the eyes to heal. Switching to daily disposable lenses or rigid gas-permeable lenses can help reduce irritation. Antihistamine or anti-inflammatory eye drops may be prescribed to alleviate symptoms. Improving lens hygiene and reducing lens wear time are also important preventive measures.

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